La aparición de las modernas técnicas de modificación genética (CRISPRCas9) ha abierto maravillosas expectativas en el campo de la biomedicina. Sin embargo, su aplicación sobre la línea germinal humana despierta todavía una fuerte oposición por parte de amplios colectivos. A menudo se aduce que factores como el riesgo que implica esta técnica, su propia futilidad, la amenaza implícita a la integridad del genoma humano, o la posibilidad de que acaben dando naturaleza a una nueva eugenesia justifican la necesidad de trazar (...) una prohibición o, al menos, una moratoria sobre ellas. En este texto debatiremos la solvencia de cada uno de estos argumentos, concluyendo que, en realidad, no hay buenos motivos para oponerse a la técnica que nos ocupa. (shrink)

Hailed by the Journal of the History of Astronomy as "charming and witty," this chronicle by a renowned physicist traces the development of scientific thought from the works of the "founding fathers" — Galileo, Huygens, and Newton — to the more recent discoveries of Maxwell, Boltzmann, and Gibbs. 1984 edition.

Le présent ouvrage comble une lacune. La recherche, en effet, n'avait jamais pris en vue de manière systématique et détaillée l'ensemble de la philosophie schellingienne dans son rapport à la théologie. (C'est d'autant plus surprenant si l'on se rappelle que la pensée de Schelling représente le dernier essai de grand style d'établir une médiation entre ces deux disciplines.) En pratiquant sur toute l'œuvre une coupe longitudinale - depuis les premiers écrits critiques sur le mal et le mythe, à travers la (...) spéculation théogonique des Ages du monde, jusqu'aux développements christologiques et ecclésiologiques de la dernière période - le livre retrace le devenir de la théologie de Schelling, s'intégrant dans sa pensée comme l'une de ses composantes. Cette méthode permet de mettre en évidence la façon dont le philosophe théologien s'est critiqué lui-même dans les diverses phases de sa longue carrière et a modifié ses positions initiales pour tenter d'échapper à la synthèse idéaliste de la foi et du savoir, sans parvenir toutefois à se dégager entièrement du schéma de l'identité. (shrink)

Grace a son interrogation incomparablement tenace et incisive sur le sens de l'etre, la pensee heideggerienne accede a une comprehension du sacre qui semble irreductible a tout autre, et qui, par son originalite et sa profondeur, compte parmi les plus significatives elaborees a notre epoque. Le present ouvrage etudie le rapport complexe entre cette notion du sacre et les eclaircissements heideggeriens sur le divin et la mediation poetique. Il s'articule en quatre parties, dont la premiere expose la genese de l'interpretation (...) heideggerienne du sacre. La deuxieme partie propose une etude thematique du nouveau lexique que Heidegger, au contact notamment de la poesie de Holderlin, introduit dans sa meditation du sacre. La troisieme partie entreprend une serie de discernements critiques, en se laissant instruire par les principaux travaux qui ont examine explicitement la comprehension heideggerienne du sacre, du divin, et du poete. Dans une perspective synthetique, la quatrieme partie, enfin, s'efforce de ressaisir l'approche de Heidegger par le biais de ce qui la deborde, en la faisant dialoguer avec d'autres pensees philosophiques et theologiques marquantes; ce qui conduit a considerer, entre autres, la difference du sacre et du Saint. Degage a partir des developpements diachroniques de la premiere partie, le triptyque du sacre, du divin, et du poete structure aussi bien les synchronisations thematiques de la deuxieme partie que les discernements critiques fournis par la troisieme, et il est assume, tout en etant "depasse", par les chapitres systematiques de la derniere partie. (shrink)

We present a preliminary high-level formal theory, grounded on knowledge representation techniques and foundational ontologies, for the uniform and integrated representation of the different kinds of (quali- tative and quantitative) knowledge involved in the designing process. We discuss the conceptual nature of engineering design by individuating and analyzing the involved notions. These notions are then formally charac- terized by extending the DOLCE foundational ontology. Our ultimate purpose is twofold: (i) to contribute to foundational issues of design; and (ii) to support (...) the development of advanced modelling systems for (qualitative and quantitative) representation of design knowledge. (shrink)

Product structures are represented in engineering models by depicting and linking components, features and assemblies. Their understanding requires knowledge of both design and manufacturing practices, and yet further contextual reasoning is needed to read them correctly. Since these representations are essen- tial to the engineering activities, the lack of a clear and explicit semantics of these models hampers the use of information systems for their assessment and exploita- tion. We study this problem by identifying different interpretations of structure rep- resentations, (...) and then discuss the formal properties that a suitable language needs for representing components, features and combinations of these. We show that the representation of components and features require a non-standard mereology. (shrink)

Providing the first English translation of Análisis del ser del mexicano, this book features a full biography of Uranga, a detailed overview of the translated text, and discussion of Uranga's relevance to contemporary debates in the phenomenology of culture, the philosophy of liberation, Latin American philosophy and phenomenology itself. Reading Uranga's brilliant words expertly translated and introduced by Carlos Alberto Sánchez finally allows us to understand why this Mexican philosopher is considered one of the most fearless and original thinkers of (...) the 20th century. (shrink)

The parallel distributed processing (PDP) perspective brings forward the important point that all semantic phenomena are based on analog underlying mechanisms, involving the weighted summation of multiple inputs by individual neurons. It falls short of indicating, however, how the essentially discrete nature of semantic processing may emerge at the cognitive level. Bridging this gap probably requires attractor networks.

The act of iudicare hostes (‘declare public enemy’) was a formal pronouncement of the Roman Senate, voted for the first time in 88 BCE following a proposal by L. Cornelius Sulla after his first march on Rome. Legal historians have generally interpreted it as an emergency measure intended to preserve legality in a situation of civil strife and viewed it as a consistently defined institutional framework throughout the final decades of the Republic. Through an analysis of Sulla’s performative political communication, (...) before, during and in the immediate aftermath of the march, this paper argues that the act of judging (iudicare) someone a public enemy (hostis publicus) was first deployed as a political action, void of legal effects. Later instances of iudicare suggest that this act underwent a process of institutionalization after 63 BCE. (shrink)

In this paper I attempt to bring together (at least) two very different debates: one on justice, mercy and particularity, the other on the play of exclusionary reasons. My aim is to show how the discussion of the uneasy co-existence of justice and mercy pivots on the question of particularity. And, secondly, that the debate on exclusionary reasons can show us why law may fail to do justice in this context.

Stakeholder engagement and dialogue have a central role in defining the relations between organisations and their internal and external interlocutors. Drawing upon the analysis of dialogic motifs, power–conflict dynamics and sociopolitical perspectives, and based on a set of interviews with the stakeholders of a consumer-owned cooperative, the research explores the dialogic potential of stakeholder engagement. The analysis revealed a fragmented picture where the co-design and co-implementation aspects were mainly related to the non-business areas of cooperative life, while business logic dominated (...) the most central aspects. Stakeholder engagement was mainly related to consensus building, while dialogic engagement based on a pluralistic understanding was only partially considered and then neglected. The social capital in the local area, the growing size of the organisation and the related power structure embrace stakeholder engagement, influencing the orientation of the dialogic dynamic. The analysis indicates that a dialogic exchange is a relative concept which depends on the interests involved and the topics discussed. It also reveals that the key factors in the democratisation of stakeholder engagement are a mutual understanding and long-term opportunities. Common sociopolitical aspects are also important, but they do not necessarily guarantee the creation of dialogism paths. The research contributes to the critical dialogic literature in revealing whether and how stakeholder engagement has been implemented in a specific setting. It also shows the limitations of voluntarist stakeholder engagement initiatives. (shrink)

La obra literaria de santa Rosa de Lima se reduce a unos versos registrados en el Primer Proceso Ordinario de la jerarquía peruana y a dos medios pliegos holográficos, conservados en el convento de Santa Rosa de las Madres, de Lima. Basándose en estos datos y ahondando en el testimonio de las conclusiones obtenidas por el Dr. Juan del Castillo, tras el examen de conciencia de 1614 realizado a la Santa, el autor realiza una semblanza de la primera escritora místico-visionaria (...) de la América del virreinato. (shrink)

Includes articles about Origen, Thomas Aquinas, Hegel, Schleiermacher, Blondel, Teilhard de Chardin, Barth, Heidegger, Gadamer, postmodernism.

La decouverte de plus en plus profonde de la signification du christianisme a transforme la pensee de Fichte. Reciproquement, Fichte s'engage dans la voie d'une transformation du christianisme, au sens d'une metamorphose de la croyance en vision; il saisit la foi comme un stade imparfait de la science et souligne que seule cette derniere est a meme de supprimer l'exteriorite de l'Absolu. Le present ouvrage allie les points de vue genetique et systematique. De ses cinq parties, les quatre premieres exposent, (...) en suivant l'ordre chronologique, l'evolution de la theorie fichteenne du christianisme, depuis les textes prekantiens jusqu'a la Doctrine de l'Etat de 1813. La longue cinquieme partie, structuree thematiquement plutot que chronologiquement, est reservee non seulement a la reprise synthetique, mais aussi a la confrontation critique. Elle examine les differents aspects de la conception fichteenne du christianisme, notamment sa position a l'egard du Nouveau Testament, de la dogmatique, de la morale et de la mystique chretiennes. (shrink)

The introduction looks at the constitutional situation in Chile since the demand for a new Constitution erupted in demonstrations all across the country, and argues that the notion of ‘constitutional moment’ is inadequate to capture the radicality of the popular mobilisation that is sweeping the country as a pure expression of constituent power.

In this paper I take issue with and argue against a certain subordination of the political to the legal that, I argue, is advanced under theories or ‘republican constitutionalism’ and undertake a defense of the political as ‘reflexive’. In republican constitutionalism one discerns an ‘imperialistic’ legal move to set the terms of political discourse, as political conflicts in order to be legally resolved are forced to meet criteria of legal relevance: in the process much that is vital to political action, (...) its understanding and undertaking, is suppressed, elided or appropriated. I argue against the purported ‘containment’ of politics in law and for a ‘reflexivity’ that is constitutive of politics, re-introducing contingency and selfreference (‘what is political can only be a political question’) at the heart of what it means to act politically. (shrink)

Cet ouvrage important reflète le dynamisme actuel en Espagne de la recherche en histoire des femmes, tout en vérifiant la diversité théorique, méthodologique et thématique de ce courant historiographique. Afin de faciliter la présentation nous regroupons par thèmes les 24 travaux inclus dans cette vaste publication. En premier lieu, distinguons les contributions orientées vers l’analyse théorique. Mª Isabel del Val Valdivieso dans « A modo de introducción. La historiografía en los albores del...

To think a Deleuzian politics requires to understand the philosophical markleft in his work by Spinoza. Both philosophers’ paths crisscross in their problems, questions and consequences. In this paper three concepts will be put in relation: critique, right and crowd. The aim is to elucidate how man can open new ways of political experience from the conjunction of two philosophies articulated upon a common ground: immanence and life.

The aim of this text is to develop an epistemological-technique approach which permit analyze the work of Juan Downey, and his use of technical medias and also include the struggle against the State in the political and cultural model of the primitive societies of the Yano- mani, particularly by the work of Pierre Clastres and Jacques Lizot, and also their point of view of the methods of production in the societies of abundance, as theorized the anthropologist Marshall Sahlins, considering these (...) anthropological paradigms as a medium to understand the mediatic interaction and the technique development in the works of Juan Downey. (shrink)

The aim of this text is to develop an epistemological-technique approach which permit analyze the work of Juan Downey, and his use of technical medias and also include the struggle against the State in the political and cultural model of the primitive societies of the Yano- mani, particularly by the work of Pierre Clastres and Jacques Lizot, and also their point of view of the methods of production in the societies of abundance, as theorized the anthropologist Marshall Sahlins, considering these (...) anthropological paradigms as a medium to understand the mediatic interaction and the technique development in the works of Juan Downey. (shrink)

Post‐translational modifications regulate each step of DNA replication to ensure the faithful transmission of genetic information. In this context, we recently showed that deubiquitination of SUMO2/3 and SUMOylated proteins by USP7 helps to create a SUMO‐rich and ubiquitin‐low environment around replisomes that is necessary to maintain the activity of replication forks and for new origin firing. We propose that a two‐flag system mediates the collective concentration of factors at sites of DNA replication, whereby SUMO and Ubiquitinated‐SUMO would constitute “stay” or (...) “go” signals respectively for replisome and accessory factors. We here discuss the findings that led to this model, which have implications for the potential use of USP7 inhibitors as anticancer agents. (shrink)

Las exigencias del diálogo entre la fe y la cultura actual han obligado a plantearse seriamente la tarea de "inculturación" del cristianismo, una misión necesaria aunque compleja y delicada. Tras definir los términos principales del tema, se exponen los criterios a seguir y los equilibrios necesarios para su adecuada realización. A continuación se describe el objeto principal de este estudio: la inculturación de la catequesis. En primer lugar, los agentes o personas responsables de la inculturación (la comunidad cristiana, los diferentes (...) servicios o ministerios, el papel de los catequistas), los aspectos o lugares particularmente implicados (pequeñas comunidades cristianas, catequesis locales, catequesis populares, etc.). El estudio termina destacando algunos de los posibles riesgos y dificultades que la tarea de inculturar la catequesis debería intentar superar. (shrink)

The anticipation of the typical under the assumption of the non-occurrence of the atypical is the experiential schema governing the individuation of ordinary enduring objects and their properties. Against this background, a primitive form of “if-and-only-if” consciousness is implicit in our everyday perceptual intentions. The thematization of the fact that perception operates under this proto-tentative structure occurs at the level of reflection and is expressed by defeasible judgments of the form “if p, then q, unless r,” or “if p, then (...) q provided that not-r”. Here I will argue that what is made thematic by judgments containing such restrictive clauses is the structure of unpredictability inherent in what Husserl calls the horizon of latency and, indirectly, the world as background of normality. (shrink)